polymyalgia rheumatoid arthritis :: Article CreatorCancer-predisposition Variants Associated With Adverse Outcomes In Rhabdomyosarcoma
Germline cancer-predisposition variants (CPVs) can be helpful in predicting risk in some pediatric cancers. However, CPV risk association in children with rhabdomyosarcoma has not been well studied. A new report led by researchers at Baylor College of Medicine evaluates the association of germline CPVs with rhabdomyosarcoma outcomes in a cohort of children enrolled in Children's Oncology Group studies. The findings are published in JAMA Network Open.
"Compared to other pediatric cancers, survival for rhabdomyosarcoma has not improved in recent decades. One limiting factor in clinical practice is the imprecision of risk stratification strategies, which is why we wanted to study whether CPV presence can be used as a measure for high-risk cases," said corresponding author Dr. Philip Lupo, professor of pediatrics – hematology and oncology and director of the Epidemiology and Population Sciences Program at Texas Children's Cancer Center.
Researchers conducted an exome association analysis of outcomes among 580 children with rhabdomyosarcoma. The presence of CPVs in rhabdomyosarcoma-associated genes was associated with more adverse outcomes. Children with embryonal rhabdomyosarcoma and CPVs in the TP53 or HRAS gene had particularly poor outcomes. "These outcomes were not driven by a secondary malignancy, which is an important new finding that is in contrast to current understanding in the field," said Lupo, a member of the Dan L Duncan Comprehensive Cancer Center at Baylor.
Another important finding identified a group of individuals with CPVs who had not yet been recognized to have poor outcomes. Researchers observed that children with fusion-negative rhabdomyosarcoma and CPVs had comparable outcomes to children with no CPVs and fusion-positive rhabdomyosarcoma, an aggressive subtype known to have poor outcomes.
"The results of our study support germline testing for cancer-predisposition variants among children with rhabdomyosarcoma, which could aid in early clinical surveillance strategies for patients and cascade testing of family members," Lupo said.
"I'm excited that our research might lead to improving clinical guidelines for children diagnosed with rhabdomyosarcoma and their families. I hope that the findings of our paper will result in new discussions about how to improve survival for children diagnosed with cancer," said first author Dr. Bailey Martin-Giacalone, graduate student in Lupo's lab at Baylor at the time of research and currently a postdoctoral associate at Washington University in St. Louis.
Other authors of this work are He Li, Michael E. Scheurer, Dana L. Casey, Shannon Dugan-Perez, Deborah A. Marquez-Do, Donna Muzny, Richard A. Gibbs, Donald A. Barkauskas, David Hall, Douglas R. Stewart, Joshua D. Schiffman, Matthew T. McEvoy, Javed Khan, David Malkin, Corinne M. Linardic, Brian D. Crompton, Jack F. Shern, Stephen X. Skapek, Rajkumar Venkatramani, Douglas S. Hawkins, Aniko Sabo and Sharon E. Plon. They are affiliated with one or more of the following institutions: Baylor College of Medicine, Human Genome Sequencing Center at Baylor, University of North Carolina at Chapel Hill, University of Southern California, Children's Oncology Group, National Cancer Institute, University of Utah, University of Toronto, Duke University, Harvard Medical School, University of Texas Southwestern Medical Center and University of Washington.
This research was supported by the Cancer Prevention and Research Institute of Texas (CPRIT) (RP170071), the National Cancer Institute (U24CA196173, U24CA114766, U10CA098413, U10CA180899, U10CA098543, and U10CA180886), the Children's Oncology Group Foundation, the QuadW Foundation, the Isabella Santos Foundation, the St. Baldrick's Foundation, the Intramural Research Programs of the Center for Cancer Research, the Division of Cancer Epidemiology and Genetics of the National Cancer Institute, and the National Human Genome Research Institute (1UM1HG008898). See the publication for a full list of funding sources.
People With Any Of These 87 Muscle Or Joint Conditions Could Be Due Up To £737 Each Month
New figures from the Department for Work and Pensions (DWP) show that there are more than 1.1 million adults across Great Britain receiving support through Personal Independence Payment (PIP) for more than 85 musculoskeletal conditions, including 64,202 living in Scotland.
Musculoskeletal conditions are injuries and disorders that affect the human body's movement or musculoskeletal system such as muscles, tendons, ligaments, nerves, discs and blood vessels. Arthritis is a general term that refers to many of these different conditions, however, some common conditions include osteoarthritis, back pain, rheumatoid arthritis, fibromyalgia, osteoporosis, gout, polymyalgia rheumatica, lupus and ankylosing spondylitis.
If you are over 16 and under State Pension age, you may be able to claim PIP - or Adult Disability Payment (ADP) in Scotland - to help with a musculoskeletal condition, and if your ability to work is limited due to your symptoms you could be eligible for 'new style' Employment and Support Allowance (ESA).
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The new DWP figures also showed that there are now 3.5 million people in Scotland, England and Wales claiming PIP, including almost 218,859 living in Scotland. However, as more existing PIP claimants living in Scotland are transferred to ADP, that figure will decrease.
Even though new claims for PIP have been replaced in Scotland by ADP, it follows largely similar eligibility criteria, but takes a more 'people-centric' approach, according to Social Security Scotland.
A successful claim for PIP or ADP is currently worth between £26.90 and £172.75 each week in additional financial support and as the benefit is paid every four weeks, this amounts to between £107.60 and £691 every pay period.
However, from April 8 payments will rise by 6.7 per cent as part of the annual uprating exercise. This means payments will be worth between £28.70 and £184.30 each week, or £114.80 and £737.20 each pay period.
PIP claimants with musculoskeletal conditions
The latest data shows that at the end of February 2024, over one million people were receiving support through PIP for Musculoskeletal conditions.
Scotland: 64,202 (does not include case transfer or new claims of Adult Disability Payment) England and Wales: 1,036,887 Living abroad: 1,031 Total: 1,102,171 Below is the list of 87 musculoskeletal conditions being supported through PIP to help with either daily living, mobility needs or a combination of both components. It is not definitive, so if your condition does not appear, don't be put off making a claim as an award for PIP or ADP is about how the condition affects you, not the condition itself.
Musculoskeletal Conditions - General
Osteoarthritis
Osteoarthritis of Hip
Osteoarthritis of Knee
Osteoarthritis of other single joint
Primary generalised Osteoarthritis
Chronic pain syndrome
Chronic fatigue syndrome (CFS)
Fibromyalgia
Pain syndromes - Chronic - Other / type not known
Inflammatory arthritis
Ankylosing spondylitis
Arthritis - Psoriatic
Arthritis - Reactive
Inflammatory arthritis - Other / type not known
Juvenile chronic arthritis (Still's disease)
Rheumatoid arthritis
Crystal deposition disorders
Crystal deposition disorders - Other / type not known
Gout
Pseudogout
Osteonecrosis and osteochondritis
Osteochondritis
Osteonecrosis
Metabolic and endocrine disorders
Osteomalacia
Osteoporosis
Other metabolic and endocrine disorders of musculoskeletal system
Paget's disease
Rickets
Genetic disorders, dysplasias and malformations
Achondroplasia
Epiphyseal dysplasia - multiple
Genetic disorders, dysplasias and malformations - Other / type not known
Hereditary multiple exostosis (diaphyseal aclasis)
Hypermobility syndrome
Marfan's syndrome
Osteogenesis imperfecta
Benign tumours of bone
Tumours of bone - benign
Fracture complications
Compartment syndrome (Volkmann's ischaemia)
Fracture complications - Other / type not known
Sudek's atrophy
Other generalised musculoskeletal conditions
Generalised musculoskeletal disease - Other / type not known
More than one million people with a musculoskeletal condition are receiving support from PIP or Adult Disability Payment. (Image: Getty Images) Musculoskeletal Conditions - Regional
Shoulder disorders
Adhesive capsulitis (frozen shoulder)
Rotator cuff disorder
Shoulder disorders - Other / type not known
Shoulder instability
Elbow disorders
Elbow disorders - Other / type not known
Golfers elbow (medial epicondylitis)
Tennis elbow (lateral epicondylitis)
Wrist and hand disorders
Carpal tunnel syndrome
Dupuytren's contracture
Tendon lesions
Tenosynovitis
Wrist and hand disorders - Other / type not known
Neck disorders
Cervical disc lesion
Cervical spondylosis
Neck disorders - Other / type not known
Whiplash injury
Non specific back pain
Back pain - Non specific (mechanical)
Specific back pain
Back pain - Specific - Other / type not known
Kyphosis
Lumbar disc lesion
Lumbar spondylosis (OA spine)
Schuermann's disease
Scoliosis
Spinal stenosis
Spondylolisthesis
Hip disorders
Dislocation of the hip - congenital
Hip disorders - Other / type not known
Perthes disease
Slipped upper femoral epiphysis
Knee disorders
Bursitis
Chondromalacia patellae
Knee disorders - Other / type not known
Ligamentous instability of knee
Meniscal lesions
Osgood schlatters disease
Osteochondritis dissecans
Patellar dislocation - Recurrent
Ankle and foot disorders
Ankle and foot disorders - Other / type not known
Club foot (talipes)
Fore foot pain (Metatarsalgia)
Hallux valgus /rigidus
Amputations
Amputation - Lower limb(s)
Amputation - Upper limb(s)
Amputations - Upper & Lower limb/s
Injuries/fracture/Dislocation
Abdomen - Injuries/Fracture/Dislocation of
Lower limb - Injuries/Fracture/Dislocation of
Multiple - Injuries/Fracture/Dislocation
Pelvis - Injuries/Fracture/Dislocation of
Spine - Injuries/Fracture/Dislocation of
Thorax - Injury/Fracture/Dislocation of
Upper limb - Injury/Fracture/Dislocation of
Other regional musculoskeletal disease
Musculoskeletal disease - Regional / Localised - Other / type not known
Below is an overview of PIP and ADP. Even though new claims for PIP have been replaced in Scotland by ADP, it shares most of the same eligibility criteria. Full guidance on ADP can be found on the MYGOV.SCOT website here.
Who might be eligible for PIP or ADP?
To be eligible for PIP or ADP, you must have a health condition or disability where you:
You usually need to have lived in the UK for at least two of the last three years and be in the country when you apply.
In addition to what we have outlined above if you get or need help with any of the following because of your condition, you should consider applying for PIP or ADP.
preparing, cooking or eating food managing your medication washing, bathing or using the toilet dressing and undressing engaging and communicating with other people reading and understanding written information making decisions about money planning a journey or following a route moving around There are different rules if you are terminally ill, you will find these on the GOV.UK website here.
DWP or Social Security Scotland will assess how difficult you find daily living and mobility tasks. For each task they will look at:
whether you can do it safely how long it takes you how often your condition affects this activity whether you need help to do it, from a person or using extra equipment How are PIP and ADP paid?
PIP and ADP are usually paid every four weeks unless you are terminally ill, in which case it is paid weekly. It will be paid directly into your bank, building society or credit union account. ADP is paid at the same rates as PIP.
What are the PIP and ADP payment rates?
You will need an assessment to work out the level of financial help you will receive and your rate will be regularly reviewed to make sure you are getting the right support.
PIP is made up of two components:
Whether you get one or both of these and how much depends on how severely your condition affects you.
You will be paid the following amounts per week depending on your circumstances:
Daily living
Mobility
How you are assessed
You will be assessed by an independent healthcare professional to help the DWP determine the level of financial support, if any, you need, for PIP.
Face-to-face consultations for health-related benefits are offered alongside video calls, telephone and paper-based assessments - it's important to be aware that the health professional and DWP determine which type of assessment is best suited for each claimant. You can find out more about DWP PIP assessments here.
Adult Disability Payment assessments will not involve face-to-face assessments, unless this is preferred by the claimant - find out more about the changes here.
Join the conversation on our Money Saving Scotland Facebook group for energy and money-saving tips, the latest benefits news, consumer help and advice on coping with the cost of living crisis. Sign up to our Record Money newsletter and get the top stories sent to your inbox daily from Monday to Friday, including a special cost of living edition on a Thursday - sign up here. You can also follow us on X (formerly Twitter) @Recordmoney_ for regular updates throughout the day. NEW - Get our money news alerts on your phone by joining our Daily Record Money WhatsApp community. How do you make a claim for PIP?
You can make a new claim by contacting the DWP, you will find all the information you need to apply on the GOV.UK website here.
Before you call, you will need:
your contact details
your date of birth
your National Insurance number - this is on letters about tax, pensions and benefits
your bank or building society account number and sort code
your doctor or health worker's name, address and telephone number
dates and addresses for any time you've spent abroad, in a care home or hospital
How to apply for ADP
People can apply ADP, over the phone, by post or in-person. To find out more or apply, visit the dedicated pages on mygov.Scot here or call Social Security Scotland on 0800 182 2222.
Join our Daily Record Money WhatsApp community here to receive alerts on the latest money news from benefits to shopping deals.
Every Single DWP Condition Entitled To PIP And How Successful They Are
Cardiovascular disease - Other / type not known 49.60% Abdomen - Injuries/Fracture/Dislocation Of 55.00% Achondroplasia 86.10% Acne Vulgaris 19.70% Addison's Disease 48.70% Adhd / Add 49.70% Adhesive Capsulitis (Frozen Shoulder) 39.50% Adrenal Diseases - Other / Type Not Known 43.80% Agoraphobia 65.20% Alcohol Misuse 61.60% Allergy No Risk Of Anaphylaxis 20.30% Allergy Risk Of Anaphylaxis Unknown Or Not Fully Assessed 27.50% Allergy With A Risk Of Anaphylaxis 26.50% Amblyopia 59.20% Amino Acid Metabolism - Disorders Of 37.10% Amputation - Lower Limb(S) 88.50% Amputation - Upper Limb(S) 76.70% Amputations - Upper & Lower Limb/S 91.30% Amyloidosis 82.10% Anaemia - Aplastic 59.40% Anaemia - B12 (Pernicious)/Folate Deficiency 35.10% Anaemia - Iron Deficiency 33.50% Anaemia - Sickle Cell 48.60% Anaemias - Other / Type Not Known 42.00% Aneurysm - Aortic 60.40% Aneurysm - Cerebral 64.30% Aneurysms - Other / Type Not Known 55.10% Angina 55.60% Angioedema 39.80% Angiosarcoma 90.80% Ankle And Foot Disorders - Other / Type Not Known 45.10% Ankylosing Spondylitis 70.20% Anorectal Abscess 37.30% Anorexia Nervosa 71.20% Anterior Uveitis (Iritis) 60.50% Antiphospholipid Syndrome 61.70% Anxiety Disorders - Other / Type Not Known 38.60% Aortic Valve Disease 47.80% Arterial Disease Excluding Coronary - Other / Type Not Known 57.90% Arthritis - Psoriatic 69.30% Arthritis - Reactive 68.60% Asbestosis 74.60% Ascites 76.90% Asperger Syndrome 51.10% Asthma 48.90% Astigmatism 51.50% Ataxia - Friedrich's 92.50% Ataxias - Other / Type Not Known 81.50% Atherosclerosis (Pvd / Claudication) 64.40% Atrial Fibrillation/Flutter 49.20% Atrioseptal Defect (ASD) 56.90% Attention To Artificial Opening Colostomy/Ileostomy/ Stoma - No Underlying Diagnosis 38.40% Autism 72.30% Autoimmune (Idiopathic) Thrombocytopaenic Purpura (ITP) 42.90% Autoimmune Disease - Other / Type Not Known 60.70% Autoimmune Hepatitis 45.50% Back Pain - Non Specific (Mechanical) 56.20% Back Pain - Specific - Other / Type Not Known 68.80% Bacterial Diseases - Other / Type Not Known 55.20% Bedwetting (Enuresis) 33.30% Behcet's Disease 58.00% Bipolar Affective Disorder (Hypomania / Mania) 61.30% Bladder - Cancer Of 76.50% Bladder Urethra Testes And Penis - Other Diseases Of / Type Not Known 28.00% Blepharospasm 62.20% Blood Disorders - Type Not Known 51.00% Blood Vessels/Lymphatics - Other Diseases Of / Type Not Known 57.30% Body Dysmorphic Disorder (BDD) 51.80% Bone - Other Cancers Of / Type Not Known 85.90% Bowel (Colon Recturm Anus) - Cancer Of 87.20% Brachial Plexus 76.10% Bradycardia 36.90% Brain And Spinal Cord - Cancer Of 91.30% Breast - Cancer Of 80.20% Bronchiectasis 65.10% Bronchus - Cancer Of 96.60% Buerger's Disease 70.30% Bulimia Nervosa 57.00% Bullous Disease - Other / Type Not Known 40.10% Burns 61.30% Bursitis 50.20% Cancers - Other / Type Not Known 78.40% Carbohydrate Metabolism - Disorders Of 58.80% Cardiac Arrhythmia - Pacemaker/Implantable Defibrillator Fitted 52.10% Cardiac Arrhythmias - Other / Type Not Known 44.10% Cardiac Failure 66.10% Cardiomyopathy 56.30% Cardiovascular Disease - Other / Type Not Known 49.70% Carpal Tunnel Syndrome 45.90% Cataplexy 50.30% Cataract 58.00% Cellulitis 65.70% Cerebral Palsy - Ataxic 87.30% Cerebral Palsy - Athetoid 98.50% Cerebral Palsy - Diplegic 88.70% Cerebral Palsy - Hemiplegic 88.40% Cerebral Palsy - Other / Type Not Known 86.70% Cerebral Palsy - Quadriplegic 99.50% Cerebrovascular Accident (Stroke) 78.30% Cerebrovascular Disease - Other / Type Not Known 67.70% Cervical Disc Lesion 64.60% Cervical Spondylosis 65.90% Cervix - Cancer Of 84.30% Charcot Marie Tooth Disease 75.20% Chondromalacia Patellae 54.30% Chondrosarcoma 85.60% Chorioretinal Disorders - Other / Type Not Known 65.50% Chromosomal Syndrome - Other Type / Not Known 77.40% Chronic Fatigue Syndrome (CFS) 54.80% Chronic Obstructive Pulmonary Disease (COPD) Chronic Bronchitis/Emphysema 66.30% Chronic Secretory Otitis Media 28.00% Chronic Suppurative Otitis Media 35.20% Cirrhosis - Alcohol Induced 64.80% Cirrhosis - Autoimmune 54.50% Cirrhosis - Other / Type Not Known 60.70% Cleft Lip 52.60% Cleft Lip With Cleft Palate 34.20% Clotting Disorders - Other / Type Not Known 49.40% Club Foot (Talipes) 51.90% Coarctation Of The Aorta 48.10% Coeliac Disease 27.70% Cognitive Disorder Due To Stroke 88.60% Cognitive Disorders - Other / Type Not Known 80.10% Collagen And Elastic Tissue - Other Diseases Of / Type Not Known 48.00% Colon - Other Diseases Of / Type Not Known 40.10% Compartment Syndrome (Volkmann's Ischaemia) 66.70% Complications Of Prematurity 73.20% Conduct Disorder (Including Oppositional Defiant Disorder) 58.30% Conductive Hearing Loss - Other Causes Of / Type Not Known 31.50% Conductive Hearing Loss Due To Trauma 31.70% Conjunctiva Cornea Eyelids And Lacrimal Apparatus - Other Diseases Of / Type Not Known) 54.80% Constipation 28.40% Conversion Disorder (Hysteria) 79.10% Corneal Ulceration 51.50% Coronavirus COVID-19 47.00% Cortical Blindness 92.30% Creutzfeldt - Jacob Disease (CJD) 100.00% Crohns Disease 30.70% Crystal Deposition Disorders - Other / Type Not Known 48.40% Cushing's Syndrome 60.00% Cystic Fibrosis 61.30% Deafness - Congenital 76.20% Deep Vein Thrombosis 51.30% Degenerative Neuronal Diseases - Other / Type Not Known 89.10% Dementia 94.10% Depressive Disorder 50.70% Dermatitis Herpetiformis 33.70% Dermatomyositis 73.80% Diabetes Insipidus 45.70% Diabetes Mellitus (Category Unknown) 45.60% Diabetes Mellitus Type 1 (Insulin Dependent) 28.20% Diabetes Mellitus Type 2 (Non Insulin Dependent) 45.80% Diabetic Neuropathy 73.40% Diabetic Retinopathy 77.80% Diplopia (Double Vision) 45.70% Disease Affecting Hearing & Balance - Other/ Type Not Known 44.60% Dislocation Of The Hip - Congenital 77.90% Dissociative Disorders - Other / Type Not Known 69.90% Disturbances Of Consciousness - Non-Epileptic - Other / Type Not Known 55.70% Diverticular Disease / Diverticulitis 33.70% Dizziness - Cause Not Specified 39.60% Down's Syndrome 99.60% Drop Attacks 62.40% Drug Misuse 56.90% Dupuytrens Contracture 54.00% Dyslexia 22.30% Dyspraxia 45.50% Dystrophia Myotonica 76.90% Eating Disorders Not Otherwise Specified (EDNOS) 60.90% Eczema - Varicose 28.40% Eczema (Dermatitis) 20.40% Ehlers Danlos Syndrome 69.20% Elbow Disorders - Other / Type Not Known 42.60% Empyema 62.80% Endocrine Diseases - Other / Type Not Known 45.30% Endometriosis 34.50% Endometrium (Uterus / Womb) - Cancer Of 86.20% Entropion 50.00% Epidemolysis Bullosa 57.80% Epiphyseal Dysplasia - Multiple 78.50% Essential Tremor - Benign 66.00% Ewing's Sarcoma 88.00% Extrinsic Allergic Alveolitis 84.20% Eye Movement - Other Disorders Of / Type Not Known 48.70% Eyes - Injuries To 36.40% Facioscapulohumeral Dystrophy 82.90% Factitious Disorders - Other / Type Not Known 52.00% Faecal Soiling (Encopresis) 23.80% Failure To Thrive 75.00% Fallots Tetralogy 44.30% Fibroids 26.30% Fibromyalgia 62.70% Fibrosarcoma 78.00% Fibrosing Alveolitis 79.50% Fistula In Anus 32.10% Food Intolerance 21.00% Fore Foot Pain (Metatarsalgia) 44.30% Fracture Complications - Other / Type Not Known 66.60% Fragile X Syndrome 91.90% Gallbladder And Biliary Tract - Other Diseases Of / Type Not Known 45.10% Gallstones 34.30% Gastrointestinal Tract - Other Cancers Of / Type Not Known 90.70% Gastrointestinal Tract - Other Diseases Of / Type Not Known 40.40% Generalised Anxiety Disorder 42.70% Generalised Musculoskeletal Disease - Other / Type Not Known 62.30% Generalised Seizures (With Status Epilepticus In Last 12 Months) 58.70% Generalised Seizures (Without Status Epilepticus In Last 12 Months) 50.10% Genetic Disorders Dysplasias And Malformations - Other / Type Not Known 71.90% Genitourinary Disease - Other / Type Not Known 36.20% Genitourinary Tract - Other Cancers Of / Type Not Known 84.60% Giant Cell Tumour - Malignant 78.00% Glaucoma 63.10% Glomerulonephritis 55.40% Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency 52.90% Goitre 26.50% Golfers Elbow (Medial Epicondylitis) 38.30% Gout 45.40% Granulomatous Lung Disease And Pulmonary Infiltration - Other / Type Not Known 68.80% Growth Hormone Deficiency 54.10% Guillain Barre Syndrome 80.50% Haematological System - Other Cancers Of / Type Not Known 81.90% Haemochromatosis 51.20% Haemolytic Disorders - Other / Type Not Known 54.10% Haemophilia A 57.80% Haemophilia B (Christmas Disease) 64.30% Haemorrhoids 21.10% Hallux Valgus /Rigidus 39.70% Head Injury - Cognitive And Sensorimotor Impairment 78.70% Head Injury - Cognitive Impairment 74.10% Head Injury - Sensorimotor Impairment 70.60% Headache - Other Causes Of / Cause Not Known 30.20% Hearing Loss - Mixed 41.30% Heart And Lung Transplantation 76.90% Heart Block 52.10% Heart Disease - Congenital - Other / Type Not Known 53.40% Heart Transplantation 66.50% Hemianopia 62.20% Hepatic Encephalopathy 76.80% Hepatitis - Chronic - Other / Type Not Known 51.40% Hepatitis B And D Infection 33.80% Hepatitis C Infection 53.20% Hereditary Multiple Exostosis (Diaphyseal Aclasis) 68.50% Hereditary Spherocytosis 43.10% Hernia 44.80% Herpes Zoster - Ophthalmic 44.80% Hiatus Hernia / Gastroesophageal Reflux Disease / Reflux Oesophagitis 33.70% Hip Disorders - Other / Type Not Known 67.40% Hirschprung Disease 31.60% HIV/Aids 48.60% Hodgkins Lymphoma 78.40% Huntington's Disease 85.00% Hydrocephalus 65.40% Hydronephrosis 39.40% Hyperlipidaemia 55.40% Hypermetropia (Long-Sighted) 48.10% Hypermobility Syndrome 53.40% Hyperparathyroidism 36.90% Hypersensitivity Diseases - Other / Type Not Known 36.80% Hypertension 47.10% Hypertensive Retinopathy 54.70% Hyperthyroidism (Thyrotoxicosis) Including Graves Disease 32.40% Hypoparathyroidism 36.80% Hypothalamic And Pituitary Diseases - Other / Type Not Known 43.40% Hypothyroidism (Myxoedema) 34.70% Immune System - Other Diseases Of / Type Not Known 51.70% Inborn Errors Of Metabolism - Other / Type Not Known 53.40% Incontinence - Stress 15.70% Incontinence - Urge 13.70% Incontinence (Not Enuresis/Bed Wetting) - Other / Type Not Known 20.60% Infections - Other 72.30% Infections - Other / Type Not Known 46.30% Infectious Diseases - Other / Type Not Known 59.60% Inflammatory Arthritis - Other / Type Not Known 67.10% Interstitial Nephritis 56.40% Irritable Bowel Syndrome (IBS) 26.10% Ischaemic Heart Disease - Other / Type Not Known 56.90% Juvenile Chronic Arthritis (Still's Disease) 69.20% Keratitis 46.50% Keratoconus 50.50% Kidney - Cancer Of 88.80% Kidney Disease - Other / Type Not Known 53.60% Knee Disorders - Other / Type Not Known 52.50% Kyphosis 68.50% Labyrinthitis 34.90% Larynx - Cancer Of 83.70% Learning Disability - Other / Type Not Known 89.40% Leg Ulcers (Arterial) 68.10% Leg Ulcers (Venous) 65.80% Leukaemia - Lymphoblastic - Acute 85.50% Leukaemia - Lymphocytic - Chronic 67.20% Leukaemia - Myelogenous (Myeloid) Acute 89.20% Leukaemia - Myeloid - Chronic 71.40% Leukaemias - Other / Type Not Known 73.40% Ligamentous Instability Of Knee 53.00% Liver - Cancer Of 93.30% Liver Failure - Features Of - Other / Features Not Known 68.40% Liver Transplantation 57.90% Lower Limb - Injuries/Fracture/Dislocation Of 55.60% Lower Respiratory Tract - Other Diseases Of / Type Not Known 59.40% Lumbar Disc Lesion 74.90% Lumbar Spondylosis (OA Spine) 75.70% Lung Cancers - Other 96.00% Lung Transplantation 82.00% Lymphoedema 71.60% Macular Degeneration 78.60% Malaria 61.50% Malformations Of The Heart - Congenital - Other / Type Not Known 50.00% Marfan's Syndrome 62.40% Mastoiditis 25.90% Melanoma 86.60% Menieres Disease 41.90% Meniscal Lesions 50.20% Mesothelioma 98.90% Metabolic Diseases - Other / Type Not Known 53.10% Metabolic Red Cell Disorders - Other / Type Not Known 61.30% Migraine 26.70% Mitral Valve 49.90% Mood Disorders - Other / Type Not Known 51.60% Motor Neurone Disease 97.50% Mouth/Tongue - Cancer Of 84.30% Movement Disorders - Other / Type Not Known 74.00% Multiple - Injuries/Fracture/Dislocation 69.20% Multiple Sclerosis 78.90% Munchausen Syndrome 57.10% Muscle - Other Diseases Of / Type Not Known 74.40% Muscular Dystrophy - Becker Type 82.60% Muscular Dystrophy - Duchenne 97.00% Muscular Dystrophy - Limb Girdle 88.40% Muscular Dystrophy - Other / Type Not Known 84.10% Musculoskeletal Disease - Regional / Localised - Other / Type Not Known 56.00% Myasthenia Gravis 66.50% Myeloma 88.20% Myocardial Infarction 48.70% Myopia (Short-Sighted) 57.70% Narcolepsy 47.40% Neck Disorders - Other / Type Not Known 52.00% Nephrotic Syndrome 52.30% Neuroblastoma 76.80% Neurofibromatosis 61.10% Neurological Disorders - Other / Type Not Known 66.20% Neuropathies - Other / Type Not Known Including Peripheral 63.30% Non Epileptic Attack Disorder (Pseudoseizures) 59.20% Non Hodgkins Lymphoma 80.40% Nystagmus 65.80% Obesity 78.10% Obsessive Compulsive Disorder (OCD) 54.30% Oesophageal Varices 48.10% Oesophagus - Cancer Of 93.60% Oesophagus Stomach And Duodenum - Other Diseases Of / Type Not Known 41.90% Old Age 83.60% Optic Atrophy 84.40% Optic Neuritis 66.40% Oral Allergy Syndrome 11.60% Orbital Cellulitis 23.80% Osgood Schlatters Disease 41.50% Osteoarthritis Of Hip 73.80% Osteoarthritis Of Knee 64.20% Osteoarthritis Of Other Single Joint 56.50% Osteochondritis 69.00% Osteochondritis Dissecans 61.70% Osteogenesis Imperfecta 74.10% Osteomalacia 72.30% Osteonecrosis 74.70% Osteoporosis 67.60% Osteosarcoma 85.30% Other Metabolic And Endocrine Disorders Of Musculoskeletal System 61.80% Otitis Externa - Chronic 30.80% Otosclerosis 34.40% Ovarian Cyst (Benign) 39.70% Ovary - Cancer Of 91.10% Ovary Uterus Cervix Vagina And Vulva - Other Diseases Of / Type Not Known 37.60% Paget's Disease 75.30% Pain Syndromes - Chronic - Other / Type Not Known 64.80% Pancreas - Cancer Of 96.70% Pancreas - Other Diseases Of / Type Not Known 51.00% Pancreatitis - Chronic 53.40% Panic Disorder 46.10% Papulosquamous And Inflammatory Rashes - Other / Type Not Known 31.90% Paraplegia (Traumatic) 97.80% Parathyroid Diseases - Other / Type Not Known 39.20% Parkinson's Disease 83.10% Parkinson's Syndrome / Parkinsonism 86.40% Partial Seizures (With Status Epilepticus In Last 12 Months) 47.60% Partial Seizures (Without Status Epilepticus In Last 12 Months) 40.20% Patellar Dislocation - Recurrent 58.70% Patent Ductus Arteriosus (PDA) 46.80% Pelvic Inflammatory Disease (PID) 41.40% Pelvis - Injuries/Fracture/Dislocation Of 67.90% Pemphigoid 36.60% Pemphigus Vulgaris 39.10% Peptic Ulcer (Gastric And Duodenal)/Gastritis 38.80% Pericarditis 40.80% Peripheral Nerve Injury - Other / Type Not Known 60.00% Peripheral Venous Disease - Other / Type Not Known 59.10% Peritonitis 71.70% Personality Disorder 61.80% Perthes Disease 67.20% Phobia - Social 44.70% Phobia - Specific 45.60% Platelet Disorders - Other / Type Not Known 43.60% Pleura - Other Diseases Of / Type Not Known 58.10% Pleural Effusion 60.90% Pneumoconiosis - Coalworkers 91.70% Pneumoconiosis - Other / Type Not Known 71.30% Pneumonia 60.30% Pneumothorax 38.20% Poliomyelitis And Post Polio Syndrome 86.20% Polyarteritis Nodosa 73.70% Polycythaemia 52.20% Polymyalgia Rheumatica 67.20% Polymyositis 80.90% Porphyria 60.60% Post Traumatic Stress Disorder (PTSD) 58.20% Posterior (Choroiditis) 73.50% Posterior Vitreous Detachment 41.50% Presbyacusis 33.30% Pressure Sores 79.00% Primary Biliary Cirrhosis (PBC) 52.80% Primary Cancer - Site Not Known 95.10% Primary Generalised Osteoarthritis 74.00% Prostate - Cancer Of 75.80% Prostatic Disease 30.10% Protozoal Diseases - Other / Type Not Known 70.00% Pseudogout 69.60% Psoriasis 35.90% Psychiatric Disorders Of Childhood - Other / Type Not Known 66.70% Psychotic Disorders - Other / Type Not Known 68.10% Ptosis 34.30% Pulmonary Embolus 52.90% Pulmonary Fibrosis - Other / Type Not Known 81.80% Pulmonary Valve Disease 64.30% Quadrantanopia 64.00% Raynaud's Disease/Phenomenon 41.60% Rectal Prolapse 35.30% Rectum/Anus - Other Diseases Of / Type Not Known 33.00% Refractive Errors - Other / Type Not Known 59.30% Renal Calculi 43.00% Renal Failure - Acute 68.70% Renal Failure - Chronic 71.10% Renal Transplantation 51.70% Respiratory Tract - Other Cancers Of / Type Not Known 84.80% Retina And Optic Nerve - Other Diseases Of / Type Not Known 76.80% Retinal Artery Occlusion 53.50% Retinal Detachment 63.20% Retinal Vein Occlusion 53.20% Retinitis Pigmentosa 87.20% Retinopathy - Other / Type Not Known 78.10% Retts Disorder 90.60% Rheumatoid Arthritis 74.70% Rickets 73.30% Rosacea 25.60% Rotator Cuff Disorder 42.10% Sarcoidosis 59.10% Sarcomas - Other / Type Not Known 87.20% Schizoaffective Disorder 71.50% Schizophrenia 69.70% Schuermann's Disease 65.90% Scleritis 32.70% Scoliosis 61.30% Scotoma 53.80% Seizures - Unclassified 54.10% Sensorineural Hearing Loss - Other Causes Of / Type Not Known 43.90% Sensorineural Hearing Loss Due To Trauma 48.20% Shoulder Disorders - Other / Type Not Known 38.50% Shoulder Instability 43.50% Silicosis 52.40% Sjogren's Syndrome 56.10% Skin Cancers - Other / Type Not Known 76.10% Skin Disease - Other / Type Not Known 38.80% Sleep Apnoea - Obstructive 28.80% Slipped Upper Femoral Epiphysis 68.40% Small Bowel - Other Diseases Of / Type Not Known 35.00% Somatoform Disorders - Other / Type Not Known 65.70% Specific Learning Disorder - Other / Type Not Known 67.50% Speech Or Language Disorder 58.40% Spina Bifida 85.40% Spinal Cord Compression - Other Causes Of / Cause Not Known 84.60% Spinal Stenosis 79.90% Spine - Injuries/Fracture/Dislocation Of 75.10% Spondylolisthesis 75.70% Steatohepatitis - Non-Alcoholic (NASH) 50.90% Stokes Adams Attacks (Cardiovascular Syncope) 71.90% Stomach - Cancer Of 91.30% Strabismus (Squint) 35.50% Stress Reaction Disorders - Other / Type Not Known 35.70% Sudek's Atrophy 85.90% Syncope - Other / Type Not Known 51.30% Syringomyelia / Syringobulbia 80.50% Systemic Lupus Erythematosus (SLE) 62.80% Systemic Sclerosis (Scleroderma) 71.80% Tachycardia 40.80% Temporal (Giant Cell) Arteritis (Headache) 57.80% Tendon Lesions 40.90% Tennis Elbow (Lateral Epicondylitis) 33.10% Tenosynovitis 46.70% Testicle - Cancer Of 65.00% Tetraplegia (Traumatic) 99.10% Thalassaemia 46.20% Thorax - Injury/Fracture/Dislocation Of 47.80% Thyroid Diseases - Other / Type Not Known 35.60% Torticollis 56.20% Tourette's Syndrome 48.60% Tracheo-Oesophageal Fistula/Atresia 53.40% Transient Ischaemic Attacks (Tias) 51.00% Transplant Rejection - Renal 74.30% Tricuspid Valve Disease 43.40% Tuberculosis 57.30% Tumours - Benign - Other / Type Not Known 58.90% Tumours Of Bone - Benign 64.90% Tumours Of The Gastrointestinal Tract - Benign 52.40% Tunnel Vision 63.60% Ulcerative Colitis 23.20% Upper Limb - Injury/Fracture/Dislocation Of 45.40% Upper Respiratory Tract - Other Diseases Of / Type Not Known 54.90% Urinary Overflow 21.10% Urinary Tract Infection 32.10% Urticaria 24.10% Uterine Prolapse 31.40% Vasculitis - Other / Type Not Known 65.50% Venous Insufficiency - Chronic 61.90% Ventriculoseptal Defect (VSD) 53.40% Viral Diseases Excluding Hepatitis And Poliomyelitis -Other / Type Not Known 61.00% Vision - Other Diseases Affecting / Type Not Known 70.50% Visual Field Defects - Other / Type Not Known 70.70% Vitreous Disease - Other / Type Not Known 71.50% Vitreous Haemorrhage 65.40% Von Willebrand's Disease 43.00% Whiplash Injury 42.90% Wilms Tumour 55.20% Wilson's Disease 68.30% Wrist And Hand Disorders - Other / Type Not Known 42.10% Writer's Cramp 29.40%
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